A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, Wu H, Masliah E, Joazeiro CA, Kay SA. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2097-103. PubMed Abstract

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REAGENTS/MATERIAL:
Antibodies:
Immunohistochemistry: Primary antibodies used were rabbit anti-GFAP (Dako) and monoclonal mouse anti-nonphospho-neurofilament (SMI32) (Sternberger Monoclonals Inc.).
Protein Extraction and Western Blot Analyses: Primary bodies used: monoclonal mouse anti-tau-5 (Biosource Invitrogen), monoclonal mouse anti-human PHF phospho-tau, (AT8) (Autogen bioclear) and monoclonal mouse anti-human PHF phospho-tau (AT180) (Autogen bioclear). A monoclonal Lister antibody (clone5L11) raised against a N-terminally truncated version of human LISTERIN (starting from N713) was used.




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