|Comment by Gang Liu, Xiongwei Zhu, Barney Dwyer, Rudy J. Castellani, Hyoung-gon Lee, George Perry, Mark A. Smith
Chelation and Neurodegenerative Diseases: Nanoparticles as Proof of Concept
The notion that iron dyshomeostasis contributes to the pathogenesis of a number of neurodegenerative disorders, now including amyotrophic lateral sclerosis (Jeong et al., 2009), is well established (Castellani et al., 1995; Smith et al., 1997; Castellani et al., 2000; Sayre et al., 2000; Petersen et al., 2005; Smith, 2006). In parallel, changes in a number of iron homeostasis proteins are also altered, including heme oxygenase-1 (Smith et al., 1994; Schipper et al., 1995), ferritin (Connor et al., 1992), and iron regulatory proteins (Connor et al., 1992; Smith et al., 1998).
While clinical trials in neurodegenerative diseases using chelation therapy have been limited, such an approach has shown promise (McLachlan et al., 1993). Unfortunately, limited blood-brain barrier permeability and/or cytotoxicity with resultant side effects have limited the interpretation of...