Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Dossena S, Imeri L, Mangieri M, Garofoli A, Ferrari L, Senatore A, Restelli E, Balducci C, Fiordaliso F, Salio M, Bianchi S, Fioriti L, Morbin M, Pincherle A, Marcon G, Villani F, Carli M, Tagliavini F, Forloni G, Chiesa R. Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model. Neuron. 2008 Nov 26;60(4):598-609. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: George Perry (Disclosure)
	Submitted 18 December 2008 \| Permalink	Posted 19 December 2008
	I recommend this paper

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REAGENTS/MATERIAL:
Antibodies used were:
rabbit anti-PrP P45-66 (David Harris, Washington University in St. Louis); monoclonal mouse anti-PrP (3F4) (Richard Kascsak, Institute for Basic Research); monoclonal mouse anti-PrP (12B2) (Jan PM Langeveld, CIDC-Lelystad, the Netherlands); monoclonal mouse anti-PrP (SA65) (Gianluigi Zanusso, University of Verona, Verona, Italy); monoclonal mouse anti-PrPSc (15B3) (Alex Raeber and Bruno Oesch, Prionics, Zurich); rabbit anti-calretinin (Swant); rabbit anti-calretinin (Chemicon Millapore); rabbit anti-synaptophysin (Dako) and rabbit anti-GFAP (Dako)