Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Jimenez S, Baglietto-Vargas D, Caballero C, Moreno-Gonzalez I, Torres M, Sanchez-Varo R, Ruano D, Vizuete M, Gutierrez A, Vitorica J. Inflammatory response in the hippocampus of PS1M146L/APP751SL mouse model of Alzheimer's disease: age-dependent switch in the microglial phenotype from alternative to classic. J Neurosci. 2008 Nov 5;28(45):11650-61. PubMed Abstract

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REAGENTS/MATERIAL:
Primary antibodies used in this study included:
Western blot and dot blot: monoclonal mouse anti-Aβ_1-16 (6E10) (Sigma-Aldrich); monoclonal mouse anti-Aβ oligomers (Nu-1) (courtesy of Drs. W. Klein and M. Lambert, Northwestern University, Evanston, IL) and monoclonal mouse anti-Aβ oligomers (A11) (Biosource Invitrogen).
Immunohistochemistry: monoclonal mouse anti-Aβ (6E10) (Sigma Aldrich); monoclonal rat anti-CD11b (Serotec); chicken anti-GFAP (Dako); monoclonal Hamster anti-CD3 (BD PharMingen); monoclonal rat anti-TNFα (MP6-XT22) (Abcam); rabbit anti-iNOS (Transduction Laboratories); goat anti-IL4 (SantaCruz) and goat anti-AMCase (YM-1) (SantaCruz)