Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Lo Bianco C, Shorter J, Régulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P. Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. J Clin Invest. 2008 Sep;118(9):3087-97. PubMed Abstract

	Comments on Paper and Primary News

	Primary News: Taking a Leaf From Plants—Hsp104 Helps Rats Cope With Synuclein Comment by: Bharathi Shrikanth Gadad
	Submitted 17 August 2008 \| Permalink	Posted 22 August 2008
	I recommend this paper

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REAGENTS/MATERIAL:
The following primary Abs were used:
sheep anti-Tyrosine Hydroxylase (Pel-Freez Biologicals); polyclonal rabbit anti-α-synuclein (RG syn), generated against the 101-124 aa sequence of human α-syn (Lo Bianco et al., 2002); mouse monoclonal anti-α-synuclein (LB509) (Zymed); anti-α-synuclein phosphorylated at Ser 129, (Fujiwara et al., 2002); rabbit anti-Hsp104 C-terminus (Stressgen); anti-oligomer Ab (C. Glabe, University of California, Irvine, California, USA) and mouse monoclonal anti-α-synuclein (42) (BD Biosciences)