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Home: Papers of the Week
Annotation


Petanceska SS, Gandy S. The phosphatidylinositol 3-kinase inhibitor wortmannin alters the metabolism of the Alzheimer's amyloid precursor protein. J Neurochem. 1999 Dec;73(6):2316-20. PubMed Abstract

Comments on Related Papers
  Related Paper: Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.

Comment by:  Benjamin Wolozin, ARF Advisor (Disclosure)
Permalink

Wortmannin is too toxic to be used as a therapeutic, but the idea of using such inhibitors is important to be aware of.

View all comments by Benjamin Wolozin
  Related Paper: Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.

Comment by:  John Hardy, ARF Advisor
Permalink
  I recommend this paper

"An interesting paper which shows yet another way of reducing plaque load... as a result of the transgenic work, there are now many hopeful avenues for the drug industry and academics to look for Alzheimer treatments."

View all comments by John Hardy
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Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin.
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