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Home: Papers of the Week
Annotation


Silverberg GD, Mayo M, Saul T, Fellmann J, Carvalho J, McGuire D. Continuous CSF drainage in AD: results of a double-blind, randomized, placebo-controlled study. Neurology. 2008 Jul 15;71(3):202-9. PubMed Abstract

Comments on Paper and Primary News
  Comment by:  John Trojanowski, ARF Advisor
Submitted 15 June 2008  |  Permalink Posted 17 June 2008
  I recommend this paper

This study of the effects of CSF drainage on a large cohort of AD patients argues against a benefit of this invasive therapy for AD patients. However, there is evidence that CSF shunting for normal pressure hydrocephalus ameliorates cognitive impairments in this enigmatic syndrome, although the reasons for this are not entirely clear (Pujari et al., 2008).

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