alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Zhang NY, Tang Z, Liu CW. alpha-Synuclein protofibrils inhibit 26 S proteasome-mediated protein degradation: understanding the cytotoxicity of protein protofibrils in neurodegenerative disease pathogenesis. J Biol Chem. 2008 Jul 18;283(29):20288-98. PubMed Abstract

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REAGENTS/MATERIAL:
Antibodies used in this study are:
mouse monoclonal anti-α-Synuclein (42) (BD Transduction); mouse monoclonal anti-polyhistidine (His-1) (Sigma Aldrich); mouse monoclonal anti-β-actin (AC-15) (Sigma Aldrich); rabbit anti-UbcH10 (Boston Biochem); rabbit anti-p21 (C-19) (Santa Cruz Biotechnology); rabbit anti-IκB-α (C-21) (Santa Cruz Biotechnology); mouse monoclonal anti-Ubiquitin (P4D1) (Santa Cruz Biotechnology) and anti-p31 polyclonal antibody (Dr. G.N. DeMartino, UT Southwestern Medical Center)




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