Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci. 1999 Oct 15;19(20):8876-84. PubMed Abstract, View on AlzSWAN

	Comments on Paper and Primary News

	Primary News: Toxic Protofibrillar Aβ Comment by: David Teplow
	Submitted 15 October 1999 \| Permalink	Posted 15 October 1999
	In the news article cited above, two important facts need clarification. First, protofibrils are fibrillar. Second, the first demonstration that protofibrils were neurotoxic was published by my group, in collaboration with Drs. Hartley, Selkoe, and others, in Walsh et al. J Biol Chem on Sept 3 (v274:25945-25952). Abstract View all comments by David Teplow

	Comment by: Alexei R. Koudinov
	Submitted 11 July 2002 \| Permalink	Posted 11 July 2002
	Please see the following letters in Science and BMJ related to this article: Alzheimer's disease and amyloid beta protein Koudinov AR et al Science online, Published 25 June 2002 [ Full Text ] Amyloid hypothesis, synaptic function, and Alzheimer’s disease, or: Beware: the dogma is revitalized. Koudinov and Koudinova BMJ 15 May 2002 [ Full Text ] View all comments by Alexei R. Koudinov

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