Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Iijima-Ando K, Hearn SA, Granger L, Shenton C, Gatt A, Chiang HC, Hakker I, Zhong Y, Iijima K. Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila. J Biol Chem. 2008 Jul 4;283(27):19066-76. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: George Perry (Disclosure)
	Submitted 4 August 2008 \| Permalink	Posted 5 August 2008
	I recommend this paper

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REAGENTS/MATERIAL:
Antibodies used:
mouse monoclonal anti-Amyloidβ (6E10) (Signet), mouse monoclonal anti-NEP (Novocastra) and anti-dCREB2 (Dr. J. Yin, University of Wisconsin)




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