Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Winton MJ, Igaz LM, Wong MM, Kwong LK, Trojanowski JQ, Lee VM. Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J Biol Chem. 2008 May 9;283(19):13302-9. PubMed Abstract

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REAGENTS/MATERIAL:
Commercial antibodies used in this study are:
rabbit anti-TDP-43 (ProteinTech Group); mouse monoclonal anti-human-TDP-43 (2E2-D3) (Abnova); mouse monoclonal anti-MAP2 (AP-14) (Lester Binder, Northwestern University); mouse monoclonal anti-myc (9E10) (Santa Cruz); anti-flag (Sigma Aldrich); mouse monoclonal anti-α-tubulin (Sigma Aldrich); mouse monoclonal anti-hnRNP A1 (4B10) (Gideon Dreyfuss, Howard Hugues Medical Institute); mouse monoclonal anti-hnRNP C1/C2 (4F4) (Gideon Dreyfuss, Howard Hugues Medical Institute)
In addition, two polyclonal antibodies were produced: rabbit anti-TDP-43, N-terminal and rabbit anti-TDP-43, C-terminal (Virginia M-Y Lee, U. Pennsylvania School of Medicine)