In this study, multimodal imaging data from the same subjects provide the authors with a unique opportunity to investigate the regional specificity of different Alzheimer’s disease pathologies. The study presents an approach to systematically put the multimodal imaging data on the same scale so that comparisons between scans are valid. This is important when comparing across modalities, and allowed the authors to investigate the regional differences between modalities. The results neatly tie together the findings in the existing literature and propose a new methodology to investigate regional hierarchy of AD pathologies. It is, however, important to remember that the modality-specific regional differences they found may be due to the differences in the specificity of the imaging technology in detecting the pathological signal. Moving forward, there is a need to employ such methodologies in subjects with longitudinal follow-up as well as in subjects covering the entire cognitive spectrum to improve our understanding of the disease.

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