Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Houlden H, Johnson J, Gardner-Thorpe C, Lashley T, Hernandez D, Worth P, Singleton AB, Hilton DA, Holton J, Revesz T, Davis MB, Giunti P, Giunti P, Wood NW. Mutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11. Nat Genet. 2007 Dec;39(12):1434-6. PubMed Abstract

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REAGENTS/MATERIAL:
Antibodies used in this study are:
anti-Digoxygenin (DIG) (Roche); mouse monoclonal anti-Aβ (6F/3D)(Dako); mouse monoclonal anti-P62 (3/P62)(BD Transduction); mouse monoclonal anti-phosoho-Tau (AT8)(Autogen Bioclear); mouse monoclonal anti-NF (C) (Sternberger Monoclonals); rabbit anti-IC2 (Chemicon); rabbit anti-ubiquitin; (Dako) and anti-GFAP (DAKO)