Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Petrushina I, Ghochikyan A, Mktrichyan M, Mamikonyan G, Movsesyan N, Davtyan H, Patel A, Head E, Cribbs DH, Agadjanyan MG. Alzheimer's disease peptide epitope vaccine reduces insoluble but not soluble/oligomeric Abeta species in amyloid precursor protein transgenic mice. J Neurosci. 2007 Nov 14;27(46):12721-31. PubMed Abstract

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REAGENTS/MATERIAL:
Antibodies used in this study are:
monoclonal rat (PE)-labeled anti-mouse CD4 (BD Biosciences); anti-IFNγ (ELISPOT kit) (BD PharMingen); anti-IL4 (ELISPOT kit) (BD PharMingen); monoclonal rat (FITC)-labeled anti-mouse CD4 (BD PharMingen); rabbit anti-Aβ42 (Invitrogen); rabbit anti-Aβ40 (Invitrogen); anti-I-A/I-E (BD PharMingen); anti-CD45 (Serotec); anti-GFAP antibodies (Eng et al., 2000); anti-CD3-ε (Santa Cruz); anti-CD4 (Novocastra); anti-CD8 (Novocastra); anti-F4/80 (Serotec); HRP-conjugated anti-oligomeric Aβ A11 polyclonal antibody (Dr. C. Glabe, University of California); monoclonal mouse Biotinylated anti-mouse Aβ (20.1); and rabbit anti-oligomeric Aβ A11 (Kayed et al., 2003).