Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Nakamoto M, Nalavadi V, Epstein MP, Narayanan U, Bassell GJ, Warren ST. Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15537-42. PubMed Abstract

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REAGENTS/MATERIAL:
Antibodies used in this study were, for immunofluorescent staining:
mouse monoclonal anti-GluR2 (6C4) (Chemicon), rabbit anti-GluR1 N-terminal (Calbiochem), mouse monoclonal anti-FMRP (gift of J. L. Mandel, Hopitaux Universitaires de Strasbourg, Strasbourg, France), rabbit anti-Synapsin I (Chemicon)