Soluble oligomers from a non-disease related protein mimic Abeta-induced tau hyperphosphorylation and neurodegeneration. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Vieira MN, Forny-Germano L, Saraiva LM, Sebollela A, Martinez AM, Houzel JC, De Felice FG, Ferreira ST. Soluble oligomers from a non-disease related protein mimic Abeta-induced tau hyperphosphorylation and neurodegeneration. J Neurochem. 2007 Oct;103(2):736-48. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Jurgen Goetz, ARF Advisor
	Submitted 13 September 2007 \| Permalink	Posted 14 September 2007
	I recommend this paper I share this view. A tau pathology is seen in a range of disorders with protein aggregates rich in beta-sheet structures. A subset of patients with British dementia develop neurofibrillary tangles (NFTs) and even in prion disorders, NFT formation has been observed. Therefore, it it not surprising (and this paper nicely supports this view) that an unrelated protein with a folding similar to Abeta can induce a tau pathology. View all comments by Jurgen Goetz

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