The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Eckermann K, Mocanu MM, Khlistunova I, Biernat J, Nissen A, Hofmann A, Schönig K, Bujard H, Haemisch A, Mandelkow E, Zhou L, Rune G, Mandelkow EM. The beta-propensity of Tau determines aggregation and synaptic loss in inducible mouse models of tauopathy. J Biol Chem. 2007 Oct 26;282(43):31755-65. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Andre Delacourte
	Submitted 3 September 2007 \| Permalink	Posted 5 September 2007
	I recommend this paper

	Comment by: Paul Coleman, ARF Advisor
	Submitted 3 September 2007 \| Permalink	Posted 5 September 2007
	I recommend this paper

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REAGENTS/MATERIAL:
Antibodies used in this study are:
rabbit anti-pan-Tau (DAKO, A0024), monoclonal mouse anti-pathological Tau conformation (MC-1) and monoclonal mouse anti-PHF-1 Tau (phospho-Ser-396 + Ser-404) (PHF-1), (both gifts from P. Davies, Albert Einstein College), mouse monoclonal anti-Tau phosphorylated KXGS motifs, Ser(P)-262, Ser(P)-356 (12E8) (gift from P. Seubert, Elan Pharma), anti-tau Ser(P)-199, Thr(P)-231, Ser(P)-214, and Ser(P)-46 recognizing phosphorylation at single SP or TP sites (custom-made, Eurogentec), mouse monoclonal anti-Tau (HT-7) (Perbio), mouse monoclonal anti-Tau (T14) (Zymed), mouse monoclonal anti-Tau phos. at Thr231 + Ser235 (AT180) (Perbio), mouse monoclonal anti-Tau phos at Ser202 + Thr205 (AT8) (Perbio)