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Zou K, Yamaguchi H, Akatsu H, Sakamoto T, Ko M, Mizoguchi K, Gong JS, Yu W, Yamamoto T, Kosaka K, Yanagisawa K, Michikawa M.
Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition. J Neurosci.
2007 Aug 8;27(32):8628-35.
PubMed Abstract, View on AlzSWAN
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REAGENTS/MATERIAL:
Antibodies used in this study are, for immunohistochemistry:
anti-Aβ1–40 and anti-Aβ1–42 end-specific polyclonal antibodies, namely, RIB40 and RIB42, respectively (IBL, Takasaki, Japan)
for Western blotting: mouse monoclonal anti-Aβ1–40 (1A10) (IBL, Takasaki, Japan), and several anti-ACE antibodies: mouse monoclonal anti-ACE (3C5) (Chemicon /Millapore), mouse monoclonal anti-ACE (2E2) (Chemicon /Millapore), mouse monoclonal anti-ACE (9B9) (RDI), mouse monoclonal anti-ACE (2E2) (Serotec), mouse monoclonal anti-ACE (QED Bioscience), goat anti-ACE (R&D Systems)
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