Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Götz J, Chen F, Van Dorpe J, Nitsch RM. Formation of neurofibrillary tangles in P301l tau transgenic mice induced by Abeta 42 fibrils. Science. 2001 Aug 24;293(5534):1491-5. PubMed Abstract, View on AlzSWAN Corresponding Author: J. Goetz

	Comments on Paper and Primary News

	Comment by: Dominic Walsh, ARF Advisor
	Submitted 18 June 2004 \| Permalink	Posted 18 June 2004
	I recommend this paper One of the most important papers of 2001. Along with Lewis, et al., this paper demonstrated a link between Aβ and tau, and importantly showed that hyperphosphorylation and aggregation of tau is precipitated by Aβ. View all comments by Dominic Walsh

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REAGENTS/MATERIAL:

Generated transgenic mice expressing a human tau mutation P301L. Mouse line designated pR5-183 used in this study.

The following antibodies were used to detect distinct tau phospho-epitopes on brain sections: AT270 (Innogenetics, 1:500, Thr-181), monoclonal AT8 (Innogenetics, 1:50, Ser-202/Thr-205), AT100 (Innogenetics, 1:100, Ser-212/Thr-214), 12E8 (P. Seubert, Elan Pharmaceuticals, 1:100, Ser-262/Ser-356), AT180 (1:100), TG3 (1:20, both for Thr-231/Ser-235); and PHF1 (1:50, P. Davies) S199P (A. Delacourte, 1:100, Ser-199), R145d (K. Iqbal, 1:30, Ser-422), pS422 (Biosource, 1:50, Ser-422), AD2 (C. Mourton-Gilles, 1:10,000, Ser-396/Ser-404), MC1 detected the conformational Alz-50 epitope (P. Davies, 1: 20), monoclonal antibody 6E10 (Signet, 1:500) was used to detect Amyloid-beta peptide, polyclonal GFAP (Sigma, 1:400) was used to detect activated astrocytes, Isolectin B4 (Vector Laboratories, 2 mg/ml) was used to detect microglia.