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Home: Papers of the Week
Annotation


Mallucci GR, White MD, Farmer M, Dickinson A, Khatun H, Powell AD, Brandner S, Jefferys JG, Collinge J. Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice. Neuron. 2007 Feb 1;53(3):325-35. PubMed Abstract

  
Comments on Paper and Primary News
  Primary News: Early Intervention Reverses Prion Disease

Comment by:  Mary Reid
Submitted 1 February 2007  |  Permalink Posted 5 February 2007

It would be interesting to see whether PDGF is also able to reverse the disease process if given during this window of opportunity. Kniazeva et al. (1997) have reported that PDGF is able to suppress PrP mRNA expression.

References:
Kniazeva M, Orman R, Terranova VP. Expression of PrP mRNA is regulated by a fragment of MRP8 in human fibroblasts. Biochem Biophys Res Commun. 1997 May 8;234(1):59-63. Abstract

View all comments by Mary Reid
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PRIMARY NEWS
Early Intervention Reverses Prion Disease
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