Sengupta S, Horowitz PM, Karsten SL, Jackson GR, Geschwind DH, Fu Y, Berry RW, Binder LI.
Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry.
2006 Dec 19;45(50):15111-9.
RELATED PAPERSA genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation.