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Home: Papers of the Week
Annotation


Sengupta S, Horowitz PM, Karsten SL, Jackson GR, Geschwind DH, Fu Y, Berry RW, Binder LI. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry. 2006 Dec 19;45(50):15111-9. PubMed Abstract

Comments on Related Papers
  Related Paper: A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.

Comment by:  John Trojanowski, ARF Advisor
Submitted 10 September 2006  |  Permalink Posted 10 September 2006
  I recommend this paper
  Related Paper: A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.

Comment by:  Takaomi Saido, ARF Advisor
Submitted 14 September 2006  |  Permalink Posted 18 September 2006
  I recommend this paper

The findings may possibly result in a breakthrough in the study of tauopathy, an essetial pathological propety of Alzheimer's disease.

View all comments by Takaomi Saido
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RELATED PAPERS
A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration.

Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation.
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