Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Engel T, Goñi-Oliver P, Lucas JJ, Avila J, Hernández F. Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. J Neurochem. 2006 Dec;99(6):1445-55. PubMed Abstract, View on AlzSWAN

	Comments on Paper and Primary News

	Comment by: Hilkka Soininen, ARF Advisor
	Submitted 29 October 2006 \| Permalink	Posted 29 October 2006
	I recommend this paper

	Comment by: John Trojanowski, ARF Advisor
	Submitted 28 October 2006 \| Permalink	Posted 29 October 2006
	I recommend this paper This interesting study has implications for tau-focused AD drug discovery, and with the inclusion of a lithium trial in the AD Cooperative Study, there will be human data to consider within a few years that will help us understand how to target tau for therapy of AD and related tauopathies. View all comments by John Trojanowski

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