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Home: Papers of the Week
Annotation


Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, Forsell C, Stenh C, Luthman J, Teplow DB, Younkin SG, Näslund J, Lannfelt L. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nat Neurosci. 2001 Sep;4(9):887-93. PubMed Abstract, View on AlzSWAN

  
Comments on Paper and Primary News
  Comment by:  Dominic Walsh, ARF Advisor
Submitted 28 June 2004  |  Permalink Posted 28 June 2004

A landmark paper, which suggests that soluble oligomeric forms of Aβ initiate disease.

View all comments by Dominic Walsh
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REAGENTS/MATERIAL:

ELISA assay to measure Amyloid-beta 40 and 42.

Western blot for APP expression used anti-APP(22C11) (Roche). Immunoprecipitation used polyclonal Amyloid-β40 end-specific antibody K12Ger.

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PRIMARY NEWS
'Arctic' APP Mutation Supports Protofibril Role
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