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Home: Papers of the Week
Annotation


Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE. Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum Mol Genet. 2006 Sep 15;15(18):2743-51. PubMed Abstract

Comments on Paper and Primary News
  Comment by:  Charles Glabe, ARF Advisor
Submitted 3 September 2006  |  Permalink Posted 3 September 2006
  I recommend this paper

Inhibitor of Htt misfolding and oligomerization reduces polyQ toxicity in vivo.

View all comments by Charles Glabe
  Comment by:  Boris Schmidt (Disclosure)
Submitted 4 September 2006  |  Permalink Posted 5 September 2006

EGCG is a frequent hitter in HTS, like many catechols. It was reported to inhibit BACE and the 20 S proteasome. Care has to be taken to work under inert atmosphere in order to avoid oxidation-derived artefacts. It's abundant in food and beverages, but does that make it a good starting point for drug development?

View all comments by Boris Schmidt
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