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Home: Papers of the Week
Annotation


Clarke EE, Churcher I, Ellis S, Wrigley JD, Lewis HD, Harrison T, Shearman MS, Beher D. Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes. J Biol Chem. 2006 Oct 20;281(42):31279-89. PubMed Abstract

Comments on Paper and Primary News
  Comment by:  Boris Schmidt (Disclosure)
Submitted 2 February 2007  |  Permalink Posted 2 February 2007
  I recommend this paper

Finally, a very sound analysis provides a model to explain the strange pharmacology of gamma-secretase modulators and inhibitors.

It can even incorporate the previous report on partial active site knock-outs.

View all comments by Boris Schmidt
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