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Home: Papers of the Week
Annotation


Leverenz JB, Fishel MA, Peskind ER, Montine TJ, Nochlin D, Steinbart E, Raskind MA, Schellenberg GD, Bird TD, Tsuang D. Lewy body pathology in familial Alzheimer disease: evidence for disease- and mutation-specific pathologic phenotype. Arch Neurol. 2006 Mar;63(3):370-6. PubMed Abstract

Comments on Paper and Primary News
  Comment by:  Takaomi Saido, ARF Advisor
Submitted 17 March 2006  |  Permalink Posted 17 March 2006
  I recommend this paper

This work is interesting in describing the difference in pathological phenptypes between PS1 and PS2 carriers. The Lewy body pathology could be a gain-of-function phenotype of PS mutations. The paper would have been more significant if the authors also included data from sporadic AD.

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