Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Rapp MA, Schnaider-Beeri M, Grossman HT, Sano M, Perl DP, Purohit DP, Gorman JM, Haroutunian V. Increased hippocampal plaques and tangles in patients with Alzheimer disease with a lifetime history of major depression. Arch Gen Psychiatry. 2006 Feb;63(2):161-7. PubMed Abstract

	Comments on Paper and Primary News

	Primary News: Dementia—Stoked by Depression or Simply Depressing? Comment by: J. Lucy Boyd
	Submitted 19 February 2006 \| Permalink	Posted 20 February 2006
	I recommend this paper

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REAGENTS/MATERIAL:

Brain sections from paraffin embedded blocks were stained using hematoxylin and eosin, modified Bielschowsky, modified thioflavin S, anti–b-amyloid and anti–t. Any case showing evidence of Lewy body formation in the substantia nigra or locus ceruleus underwent anti-ubiquitin staining (Dako Corp, Carpinteria, Calif)