So long forgotten, interest in the APLPs is slowly growing. This paper clearly demonstrates that overexpression of APLP1 leads to a dramatic change in APP processing, causing a decrease in β processing and an increase in α-processing. Although many questions remain unanswered, differential regulation of APLP/APLP2 and APP could provide a novel route for a therapy facilitating an increase in APPsα (a putative neuroprotective agent), while simultaneously achieving a decrease in the neurotoxic Aβ.

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