Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, Moechars D, Alzheimer C, Reiss K, Saftig P, De Strooper B. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. J Biol Chem. 2005 Sep 2;280(35):30797-806. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Tommaso Russo, ARF Advisor
	Submitted 11 July 2005 \| Permalink	Posted 13 July 2005
	I recommend this paper

	Comment by: Li-Huei Tsai
	Submitted 10 July 2005 \| Permalink	Posted 13 July 2005
	I recommend this paper

	Comment by: Takaomi Saido, ARF Advisor
	Submitted 9 July 2005 \| Permalink	Posted 13 July 2005
	I recommend this paper

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REAGENTS/MATERIAL:

The C terminus-specific antibody for mouse BACE1 (B48) was raised in New Zealand White rabbits using synthetic peptide CLRHQHDDFADDISLLK. Rabbit antibodies B7/8 raised against Ab and B63 raised against the C terminus of human APP were used. Anti-FLAG monoclonal antibody was from Sigma. The N terminus-specific antibody for human Ab (82E1) was from IBL Co., Ltd. (Tokyo, Japan) and used for Western blotting.




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