Interesting study linking non memory dysfunction to early synaptic markers of pre-AD. But if self appraisal (self esteem ) is to be used as a valid trigger condition to evaluate functional blood flow in hippocampal, parietal associative-, and posterior cinguli cortex, then perhaps a third patient control group (non-familial AD, depressed) should be included. Depression has deleterious effects on self esteem. Also, depression is a documented risk factor in Alzheimer disease and is often found clinically together with symptoms of cognitive involution. It opens an interesting gateway between neurology and psychiatry.

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