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Annotation


Higuchi M, Iwata N, Matsuba Y, Sato K, Sasamoto K, Saido TC. 19F and 1H MRI detection of amyloid beta plaques in vivo. Nat Neurosci. 2005 Apr;8(4):527-33. PubMed Abstract

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REAGENTS/MATERIAL:

Used APP Tg2576 tg mice to study detection of amyloid b plaques. Demonstrated for the first time that 19F- and 1H MRI using a fluorine-containing amyloidophilic probe, FSB, can specifically and definitively identify amyloid b plaques in living mice.

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