This is a thoughtful commentary on the important paper from the UC-Irvine group, published in the same issue of Neuron, which provides evidence for an early impact of intraneural A beta upon cognition in the LaFerla triple mutant model of AD.

I agree that this is not yet the final word on the subject; important impacts of intracellular and extracellular moeities of APP-derived peptides are not mutually exclusive. Our lab, however, has favored a key role for intracellular events at least since 1993 (Fukuchi et al., 1993).

View all comments by George M. Martin

It has become common to equate learning and memory deficits with "cognitive" deficits, but since changes in those domains can be demonstrated in single-cell organisms, I'll refer to them as "cognitive" when the mice write the articles.

View all comments by Emory Hill