Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. - AlzForum Alzheimer Research Paper of the Week


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Annotation

	Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18;280(7):5892-901. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Andre Delacourte
	Submitted 18 December 2004 \| Permalink	Posted 21 December 2004
	I recommend this paper

	Primary News: Curry Ingredient Spices Things Up by Blocking Aβ Aggregation Comment by: Erik Jansson
	Submitted 26 December 2004 \| Permalink	Posted 28 December 2004
	I recommend this paper Curcumin also impacts aluminum binding to chromatin DNA, which is of relevance. After aluminum mordanting of chicken blood smears, several chelating dyes and reagents were found to detect metal binding to chromatin DNA by fluorescence microscopy. One of them [the reagents] was curcumin. Aluminum is a risk factor for AD. References: A.R. Llorente, P. Del Castillo, J.C. Stockert, Aluminum binding to chromatin DNA as revealed by formation of fluorescent complexes with 8-hydroxyquinoline and other ligands. J. Microsc 155 (Pt. 2) (1989) 227-30 View all comments by Erik Jansson

	Primary News: Curry Ingredient Spices Things Up by Blocking Aβ Aggregation Comment by: J. Lucy Boyd
	Submitted 1 February 2005 \| Permalink	Posted 1 February 2005
	I recommend this paper

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