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Is the difference in the reported results explained by the fact that Borlongan and colleagues used mannitol to permealize the BBB?
The fact that mannitol is a hydroxyl radical scavenger has me wondering whether the mannitol itself may be therapeutic?
The finding by Davies et al. (1) of decreased intestinal absorption of mannitol may be of interest.
If, as suggested, GDNF from outside the brain is therapeutic in Parkinson's, might we expect that the enteric nervous system may be a natural source?
References:
Davies KN, King D, Billington D, Barrett JA. Intestinal permeability and orocaecal transit time in elderly patients with Parkinson's disease. Postgrad Med J. 1996 Mar;72(845):164-7. Abstract
Corvilain B, Schinohoritis P. Carbimazole--resistant thyrotoxicosis. Postgrad Med J. 1997 Oct;73(864):686. No abstract available. Abstract
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