The concept of combining LCM samples of sub-regions of brain with array technology offers powerful promise. These authors have, furthermore, validated selected array data by quantitative RT-PCR - an obligatory addition. Authors have taken advantage of an "experiment of nature" by comparing expression profiles of the vulnerable CA1 region with the less vulnerable CA3 region. Unfortunately, these message profiles appear to have not provided the authors with an explanation of the differential vulnerability of CA1 and CA3 in AD. This may have been due to technical limitations of much array data and analyses. On the other hand, the differential vulnerability of CA1 and CA3 may be due to post transcriptional and/or post translational events.

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