Would there be room for the suggestion that AML stem cells may also migrate to the brain to form astrocytes?
It seems of interest that Baldus et al(1) find overexpression of APP, ETS2 and ERG genes in AML.
Wolvetang and colleagues (2)show that ETS2 transactivates the beta-APP promoter.
Amouyel et al (3) report the expression of ETS proto-oncogenes in astrocytes.
Delabar et al (4) report the overexpression of ETS2 in AD.
Interesting that HIV-1 infection induces expression of c-kit (5) and Ets-2 is suggested as playing a role in the expression of c-kit. (6)
The study by Lu (7) that ETS2 transactivates the heparanase promoter and that Abeta(1-40) prevents heparanase-catalyzed degradation of heparan sulfate
glycosaminoglycans and proteoglycans in vitro (8) is also of interest.
Bitan et al (9) find that heparanase in human leukemias is restricted to acute myeloid leukemias.
Finally, the fact that ETS-2 is able to bind to the LIF promoter to induce its transcription (10) and LIF is able to increase the activity of acetylcholinesterase (11) may be something to consider....