The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Botella JA, Ulschmid JK, Gruenewald C, Moehle C, Kretzschmar D, Becker K, Schneuwly S. The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration. Curr Biol. 2004 May 4;14(9):782-6. PubMed Abstract

	Comments on Paper and Primary News

	Primary News: Sniffer Snuffs Out Stress, or Does Aging Boil Down to Oxidation? Comment by: Herbert Walker
	Submitted 17 May 2004 \| Permalink	Posted 17 May 2004
	Nice try; but is it in package form and availible over the counter? Bugs are close relatives but without applicable results it's just another nice direction without building blocks. View all comments by Herbert Walker

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REAGENTS/MATERIAL:

UAS-sni and UAS-TrxR1A flies were generated and elav-GAL4 and actin-GAL4 fly lines were obtained from the Bloomington Drosophlia Stock Center.

Western blots were probed with polyclonal anti-DNP (Molecular Probes, 1:10000) and horseradish peroxidase-conjugated doneky anti-rabbit IgG (Amersham, 1:3000). TUNEL staining performed with the immunotech MEB-STAIN apoptosis kit II.