[I would like to note] that back in [August] 2000,
we published a paper in Neurobiology of Disease (Refolo et al., Neurobiol Dis
2000) demonstrating for the first time that cholesterol metabolism accelerates
β-amyloid accumulation in a transgenic mouse model of AD. We show that diet-induced
hypercholesterolemia alters APP processing in a manner giving rise to more A-β.
What Beyreuther did was in cell lines. Our work used one of the best animals
models for AD available.View all comments by Lorenzo Refolo