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Home: Papers of the Week
Annotation


Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, Bara T, Engstrom L, Pinzon-Ortiz M, Fine JS, Lee HJ, Zhang L, Higgins GA, Parker EM. Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem. 2004 Mar 26;279(13):12876-82. PubMed Abstract, View on AlzSWAN

  
Comments on Paper and Primary News
  Primary News: New Orleans: Out Go Classic γ-Secretase Inhibitors, In Come More Dexterous NSAIDs?

Comment by:  Sigfrido Scarpa
Submitted 4 December 2003  |  Permalink Posted 8 December 2003

A mechanism to inhibit partially PS1 expression without modifying Notch activity has been postulated in our recent paper in FEBS Letters. It should be noted that the compound used is physiologically produced in the right amount in young people and strongly reduced in the elderly. We would like to see our paper considered in the course of this discussion.

References:
Scarpa S. et al. FEBS Lett 2003;541:145-148. Abstract

View all comments by Sigfrido Scarpa
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PRIMARY NEWS
New Orleans: Out Go Classic γ-Secretase Inhibitors, In Come More Dexterous NSAIDs?
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