Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT, Chang TY, Tanzi RE, Kovacs DM. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001 Oct;3(10):905-12. PubMed Abstract, View on AlzSWAN

	Comments on Paper and Primary News

	Comment by: Alexei R. Koudinov
	Submitted 7 July 2002 \| Permalink	Posted 7 July 2002
	I recommend this paper Please the following BMJ letters commenting on this article: Cholesterol, synaptic function and Alzheimer’s disease Alexei R Koudinov, Natalia V Koudinova BMJ 17 October 2001 [ Full Text ] Alzheimer’s anti-amyloid vaccination and statins: two approaches, one dogma. The time for change. Alexei R. Koudinov, Natalia V. Koudinova BMJ 20 March 2002 [ Full Text ] View all comments by Alexei R. Koudinov

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REAGENTS/MATERIAL:

Antibodies to APP were monoclonal anti-APP 22C11 (Chemicon), monoclonal anti-APP369 (gift of Dr. Sam Gandy), monoclonal anti-APPC7 (gift of Dr. Dennis Selkoe), monoclonal 4G8 (Endogen), and monoclonal anti-APP6E10 (Signet). Polyclonal anti-BACE and anti-nicastrin (Affinity BioReagents); Anti-calreticulin, anti-GM130 and anti-EEA were from StressGen Biotechnologies Corp or Transduction Laboratories. Monoclonal anti-CTF-PS1 (MSXPS1) (Chemicon) and monoclonal anti-TNF-alpha (Fitzgerald Industries International) were also used in this study.