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Home: Papers of the Week
Annotation


Singer C, Tractenberg RE, Kaye J, Schafer K, Gamst A, Grundman M, Thomas R, Thal LJ, Alzheimer's Disease Cooperative Study. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep. 2003 Nov 1;26(7):893-901. PubMed Abstract

  
Comments on Paper and Primary News
Primary News: No Rest for the Weary: Melatonin Fails Alzheimer's Trial

Comment by:  wuhua xu
Submitted 19 December 2003 Posted 19 December 2003

It's too early to say this is a final failure just because of a one-time experiment, However, if we ascribe insomina of AD patients only to their shortness of melatonin, it should be unbelieveable. Until now, we do not know the exact cause(s) and meachanism of AD. Only when we clarify them can we say whether melatonin is helpful or not for AD patients.

View all comments by wuhua xu

Primary News: No Rest for the Weary: Melatonin Fails Alzheimer's Trial

Comment by:  Jun Xu
Submitted 22 December 2003 Posted 26 December 2003

Every try is a necessary step to best treatment.

View all comments by Jun Xu

Comment by:  Edmond Devroey
Submitted 8 December 2008 Posted 15 December 2008

Dosages of 2.5 and 3 milligrams of melatonin produce short sleep and nightmares followed by drowsiness. The experiment should be repeated with more physiological dosages of 0.1 or 0.2 milligrams.

References:
The Hormone Handbook, by Thierry Hertoghe MD

View all comments by Edmond Devroey
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