Chen Y, Liu W, McPhie DL, Hassinger L, Neve RL.
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain.J Cell Biol.
2003 Oct 13;163(1):27-33.
This paper suggests a peptide that may have therapeutic potential. It also suggests the interesting possibility that a ubiquitin-like pathway may participate and promote the toxic effects induced by overexpression of WT or mutant APP.