This study by Shan et al. provides important new evidence for increased RNA oxidation and the biological consequence of the oxidized RNA in AD. Significantly increased levels of oxidized RNA nucleoside, 8-hydroxyguanosine (8OHG) were previously reported by in situ immunocytochemical analyses in vulnerable neurons of AD (Nunomura et al., 1999), Parkinson’s disease (Zhang et al., 1999
), Down’s syndrome (Nunomura et al., 2000
), and dementia with Lewy bodies (Nunomura et al., 2002
), as well as in neurons of old rats in which memory loss was associated with the levels of RNA oxidation (Liu et al., 2002
). Importantly, RNA oxidation in AD is an early-stage event in the pathological cascade (Nunomura et al., 2001
Shan et al. used a biochemical...