gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 2003 Jun 10;42(22):6664-73. PubMed Abstract

	Comments on Paper and Primary News

	Comment by: Takaomi Saido, ARF Advisor
	Submitted 22 June 2003 \| Permalink	Posted 23 June 2003
	I recommend this paper The statement in the paper, "any strategy aimed at altering APP proteolysis will have to take into account possible effects on signaling by APLP1 and 2," sounds quite logical and resonable. One remaining major remainig question is what the biological functions of the seemingly constitutively generated ICDs of APP and APLPs are. View all comments by Takaomi Saido

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