Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci. 2001 Jan 15;21(2):372-81. PubMed Abstract, View on AlzSWAN Corresponding Author: Steven G. Younkin

	Comments on Paper and Primary News

	Comment by: Benjamin Wolozin, ARF Advisor (Disclosure)
	Permalink
	I recommend this paper "This clarifies the pathophysiology of Ab greatly." View all comments by Benjamin Wolozin

	Comments on Related Papers

	Related Paper: Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Comment by: Benjamin Wolozin, ARF Advisor (Disclosure)
	Permalink
	Important new information on AD. View all comments by Benjamin Wolozin

	Related Paper: Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Comment by: Rudy Tanzi (Disclosure)
	Submitted 30 June 2003 \| Permalink	Posted 11 July 2003
	I recommend this paper

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REAGENTS/MATERIAL:
Tg mice bred by mating Tg2576 males with C47B6/SJL F1 females. Anti Abeta 1-16 MAb, BAN-50 Anti Abeta 1-40 MAb, BA-27 Anti Abeta 35-43 MAb, BC-05 Anti Abeta 11-26 MAb, BNT-77 Anti Abeta 17-24 MAb, 4G8 Anti Abeta 1-16 MAb, 6E10 Anti Abeta 1-40 polyclonal antibody, 3160 Anti C-terminal 30 aa of APP, Saeko (Kawarabayashi et al)

FUTURE DIRECTION:
Time span of Abeta aggregation in relation to the paucity of modified or oligometric form of Abeta in Tg2576 brain. Whether the decline of plasma Abeta observed in Tg2576 upon deposition of Abeta 42 and Abeta 40 also occur in human subjects.

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