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Comments on Related Papers |
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Related Paper: Reconstitution of gamma-secretase activity.
Comment by: Andre Delacourte
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Submitted 10 April 2003
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Posted 13 April 2003
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 I recommend this paper
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Related Paper: Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
Comment by: Mark Farmery (Disclosure)
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Submitted 15 May 2003
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Posted 15 May 2003
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This is an extremely important paper that, along with recent publications
from Iwatsubo et al., 2003 and Haass et al., 2003,
finally show that the γ-sceretase complex is composed of four
transmembrane proteins: presenillin, nicastrin, Aph-1 and Pen-2. It is a
clear and convincing study that builds on previous work from the same group
and brings together genetic and biochemical evidence for the structure,
function and composition of the γ-sceretase complex in a human cell
model system. Kimberly et al. show that these four components are required
for the maturation and stability of the complex, and the production of
amyloid-β. The challenge now remains to elucidate regulatory mechanisms
and substrate-specificity of the complex and to biochemically reconstitute
the components in an in-vitro system in order to rationally design
inhibitory compounds.
 View all comments by Mark Farmery |
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Related Paper: aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Comment by: John Portovski
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Submitted 4 March 2006
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Posted 5 March 2006
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I recommend this paper
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