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Polyclonal antibodies anti-APP(C7) and C8 against the C terminus of APP were a generous gift from Dr. Dennis J. Selkoe (Harvard Medical School, Boston, MA). The polyclonal antibodies against caveolin-1 came from Santa Cruz Biotechnology, Inc. (Santa Cruz, CA), and those against BACE1 were from Abcam (Cambridge, UK). Monoclonal antibodies against poly(ADP-ribose) polymerase (PARP) (C-2-10) were obtained from Clontech Laboratories, Inc. (Palo Alto, CA), and those against tumor necrosis factor- (M32255a) were from Fitzgerald Industries International, Inc. (Concord, MA). The hybridoma antibody against Notch developed by S. Artavanis-Tsakonas was obtained from the Developmental Studies Hybridoma Bank developed under the auspices of the NICHD, National Institutes of Health and maintained by the University of Iowa, Department of Biological Sciences (Iowa City, IA).