REAGENTS/MATERIAL: Primary MAb 1E8, specific for epitopes between amino acids 18 and 22 of b-amyloid (SmithKline Beecham, UK)
Rabbit Polyclonal Antibody to Tau (Dako, Glostrup, Denmark)
PCR primers for PS1 (Intron8)-F (5'-TGGGAGGTAGAAGCAGGAGGATTG-3')
PS1 (Intron9)-F (5'-CGGAACTAGAAGTTACATTGG-3')
PS1 (Intron0)-R (5'-GCAAATGTAACTCTTCCTGTCTTCCCAG-3')
FUTURE DIRECTION: Association between SP and AD, and relation to PS1 exon 9 deletion.