Variable phenotype of Alzheimer's disease with spastic paraparesis. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Smith MJ, Kwok JB, McLean CA, Kril JJ, Broe GA, Nicholson GA, Cappai R, Hallupp M, Cotton RG, Masters CL, Schofield PR, Brooks WS. Variable phenotype of Alzheimer's disease with spastic paraparesis. Ann Neurol. 2001 Jan;49(1):125-9. PubMed Abstract, View on AlzSWAN Corresponding Author: Peter R. Schofield

	Comments on Paper and Primary News

	Comment by: John Hardy, ARF Advisor
	Permalink
	I recommend this paper "A fascinating paper: including a case who died early in the disease course with only spastic paraparesis and with cotton wool plaques but no tangles." View all comments by John Hardy

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REAGENTS/MATERIAL:
Primary MAb 1E8, specific for epitopes between amino acids 18 and 22 of b-amyloid (SmithKline Beecham, UK) Rabbit Polyclonal Antibody to Tau (Dako, Glostrup, Denmark) PCR primers for PS1 (Intron8)-F (5'-TGGGAGGTAGAAGCAGGAGGATTG-3') PS1 (Intron9)-F (5'-CGGAACTAGAAGTTACATTGG-3') PS1 (Intron0)-R (5'-GCAAATGTAACTCTTCCTGTCTTCCCAG-3')

FUTURE DIRECTION:
Association between SP and AD, and relation to PS1 exon 9 deletion.