Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. - AlzForum Alzheimer Research Paper of the Week


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Home: Papers of the Week

Annotation

	Lavaute T, Smith S, Cooperman S, Iwai K, Land W, Meyron-Holtz E, Drake SK, Miller G, Abu-Asab M, Tsokos M, Switzer R, Grinberg A, Love P, Tresser N, Rouault TA. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet. 2001 Feb;27(2):209-14. PubMed Abstract

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REAGENTS/MATERIAL:

Knockgout mice Ireb2 -/- generated.

Western blot used polyclonal anti-IRP2 (against aa 137-209 of human IRP2), polyclonal rabbit anti-mouse ferritin, 1:2000; monoclonal anti-Tfre amino-terminus (Zymed).

Immunohistochemisty used anti-MAP (Lavaute, Bethesa, MD) Brain tissues of mice were stained with monoclonal-anti-calbindin, 1:1000 (Sigma); anti-ubiquitin, 1:500 (Dako).