Ohkubo N, Lee YD, Morishima A, Terashima T, Kikkawa S, Tohyama M, Sakanaka M, Tanaka J, Maeda N, Vitek MP, Mitsuda N.
Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade.FASEB J.
PubMed Abstract, View on AlzSWAN
This is a beautiful study aimed at unraveling the connection between ApoE, a prominent risk factor for AD, and intracellular signaling and tau phosphorylation. Immunohistochemistry would have been very useful in the interpretation. Perhaps the authors are working on this?